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If not satisfied with the possibilities of the Mouse-Applet in the Control Panel, then one can configure the acceleration with these DWORD registry values :

[HKEY_CURRENT_USER \Control Panel \Mouse]
MouseThreshold1 = 7 (Amount of pixels to move before going 2x normal-speed)
MouseThreshold2 = 0 (Amount of pixels to move before going 4x normal-speed)
MouseSpeed = 1 (0 = Disabled, 1 = Uses Threshold1, 2 = Uses Threshold1+2)

	Disable	Low	Medium	High	Enhanced Pointer Position
MouseThreshold1	0	7	4	4	6
MouseThreshold2	0	0	12	6	10
MouseSpeed	0	1	2	2	1

More Info MS KB Q102978
More Info MS KB Q149228

Note if the mouse pointer moves erratically or does not respond, then it might be caused by having multiple mouse drivers installed. More Info MS KB Q321122

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